Modify Therapy/Monitor Closely. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. estradiol, doxepin. Modify Therapy/Monitor Closely. Antidepressants and alcohol: What's the concern? Use Caution/Monitor. Amoxapine (prescribing information). Check for more interactions with the Drug Interaction Checker Check Now Drug Interaction Categories Using alcohol or tobacco with certain medicines may also cause interactions to occur. Mechanism: unspecified interaction mechanism. doxepin and hydroxychloroquine sulfate both increase QTc interval. Other (see comment). Contraindicated (1)doxepin and indapamide both increase QTc interval. Use Caution/Monitor. Additive anticholinergic effects.doxepin, thioridazine. For more information, please visit our page on doxepin and alcohol interactions. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. phenobarbital, doxepin. Minor/Significance Unknown. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. doxepin, prochlorperazine. Keep all medical and lab appointments. Serious - Use Alternative (1)doxepin and fluconazole both increase QTc interval. Doxepin increases the toxicity of bupropion (Wellbutrin) by unspecified interaction mechanism. Minor/Significance Unknown. Additive anticholinergic effects. doxepin and azithromycin both increase QTc interval. Consult your healthcare professional (e.g., doctor or pharmacist) for. clozapine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and apomorphine both increase QTc interval. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (1)tiotropium and doxepin both decrease cholinergic effects/transmission. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons. Serious - Use Alternative (1)doxepin and dronedarone both increase QTc interval. Use Caution/Monitor. thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and trimipramine both increase serotonin levels. Other (see comment). Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Coadministration may potentiate the CNS-depressant effects of each drug. doxepin and panobinostat both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and chloroquine both increase QTc interval. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Modify Therapy/Monitor Closely. Use lowest dose possible and monitor for respiratory depression and sedation. ethanol, doxepin. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, isoproterenol. Minor (1)doxepin increases effects of vildagliptin by pharmacodynamic synergism. Modify Therapy/Monitor Closely.paliperidone and doxepin both increase sedation. Contraindicated (1)doxepin and sotalol both increase QTc interval. Use Caution/Monitor. methocarbamol and doxepin both increase sedation. dimenhydrinate and doxepin both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (2)aripiprazole and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, terbutaline. Before doxepin, methylphenidate. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. perphenazine and doxepin both increase QTc interval. Talk to your doctor before using buPROPion together with doxepin. prochlorperazine and doxepin both increase QTc interval. Either increases effects of the other by sedation. Use Caution/Monitor. 136 are major, 503 are moderate, and 25 are minor. Serious - Use Alternative (1)palonosetron, doxepin. Use Caution/Monitor. Tricyclic antidepressants. Avoid or Use Alternate Drug. restrictions. prescription products. Minor/Significance Unknown. tapentadol and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and macimorelin both increase QTc interval. Effect of interaction is not clear, use caution. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Use Caution/Monitor. Effect of interaction is not clear, use caution. This content does not have an English version. Avoid or Use Alternate Drug. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Minor (1)ethinylestradiol, doxepin. Avoid or Use Alternate Drug. thiothixene and doxepin both increase sedation. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). rizatriptan and doxepin both increase serotonin levels. Contraindicated. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. . buprenorphine, long-acting injection and doxepin both increase QTc interval. Monitor Closely (1)lurasidone increases effects of doxepin by Other (see comment). doxepin increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. What Vitamin Deficiency Causes Burning Mouth Syndrome? Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)butalbital, doxepin. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. Monitor Closely (1)doxepin and ergotamine both increase serotonin levels. Effect of interaction is not clear, use caution. iloperidone and doxepin both increase sedation. promethazine and doxepin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor (1)verapamil increases levels of doxepin by decreasing metabolism. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and St John's Wort both increase serotonin levels. Monitor Closely (1)dipipanone and doxepin both increase sedation. http://www.wolterskluwercdi.com/facts-comparisons-online/. Monitor Closely (1)doxepin and gemifloxacin both increase QTc interval. government site. Effect of interaction is not clear, use caution. Use Caution/Monitor. doxepin and cocaine topical both increase serotonin levels. itraconazole and doxepin both increase QTc interval. Use Caution/Monitor. Exact mechanism for doxepin's sleep maintenance effect is unknown; however, doxepin's action is believed to result from antagonism of the histamine H1 receptor, Mechanism of action for depression is unknown; may increase CNS synaptic concentrations of serotonin and norepinephrine by inhibiting reuptake. Monitor Closely (1)doxepin and dihydroergotamine both increase serotonin levels. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and caffeine decreases sedation. Avoid or Use Alternate Drug. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. Monitor Closely (1)physostigmine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)oxybutynin topical and doxepin both decrease cholinergic effects/transmission. doxepin and sulfamethoxazole both increase QTc interval. Minor/Significance Unknown. Other (see comment). Use Caution/Monitor. Other (see comment). Contraindicated. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)esketamine intranasal, doxepin. Some side effects may go away after a time, while others may lead you and your doctor to try a different medication. Either increases effects of the other by Other (see comment). Use Caution/Monitor.Serious - Use Alternative (1)doxepin, ephedrine. Contraindicated. Monitor Closely (1)itraconazole and doxepin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. stiripentol, doxepin. Do not stop using any medications without first talking to your doctor. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Use Caution/Monitor. amoxapine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and scullcap both increase sedation. Contraindicated (1)selegiline and doxepin both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. This drug is available at a middle level co-pay. Please enable it to take advantage of the complete set of features! Use Caution/Monitor. hydromorphone and doxepin both increase sedation. Feighner JP, Gardner EA, Johnston JA, Batey SR, Khayrallah MA, Ascher JA, Lineberry CG. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg. doxepin and deutetrabenazine both increase sedation. Use Caution/Monitor. Monitor Closely (1)belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. official website and that any information you provide is encrypted Minor (1)conjugated estrogens, vaginal, doxepin. Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons. Sometimes cyclic antidepressants are used to treat conditions other than depression, such as obsessive-compulsive disorder, anxiety disorders or nerve-related (neuropathic) pain. Monitor Closely (1)succinylcholine increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and lithium both increase QTc interval. Monitor closely for signs of respiratory depression and sedation. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Interaction with other medicines. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Use Caution/Monitor. Monitor Closely (1)chlorpromazine and doxepin both increase sedation. Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Use Caution/Monitor. doxepin and fluoxetine both increase QTc interval. Effect of interaction is not clear, use caution. Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. Use Caution/Monitor. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)paroxetine and doxepin both increase serotonin levels. butalbital and doxepin both increase sedation. doxepin, arformoterol. Use Caution/Monitor. doxepin increases and norepinephrine decreases sedation. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. Or you may have more, or fewer, side effects from taking a specific antidepressant than someone else does. Monitor Closely (2)doxepin and hydroxyzine both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)doxepin and pholcodine both increase sedation. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and. Multiple mechanisms involved. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Serious - Use Alternative (1)doxepin and midostaurin both increase QTc interval. Minor/Significance Unknown. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Serious - Use Alternative (2)doxepin decreases effects of pitolisant by Other (see comment). Use Caution/Monitor. Monitor Closely (1)oxazepam and doxepin both increase sedation. Avoid or Use Alternate Drug.paroxetine and doxepin both increase serotonin levels. butalbital, doxepin. Contraindicated. Profound sedation, respiratory depression, coma, and death may result if coadministered. doxepin increases effects of pioglitazone by pharmacodynamic synergism. Review/update the Modify Therapy/Monitor Closely.Serious - Use Alternative (1)dolasetron, doxepin. netupitant/palonosetron, doxepin. Use Caution/Monitor.Serious - Use Alternative (1)perphenazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Use Caution/Monitor.doxepin increases effects of epinephrine racemic by unknown mechanism. fluvoxamine and doxepin both increase serotonin levels. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Discuss the risks and benefits with your doctor. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by serotonin levels. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Minor/Significance Unknown. Either increases levels of the other by pharmacodynamic synergism. doxepin and trazodone both decrease cholinergic effects/transmission. FOIA This medication is used to relieve itching from certain skin conditions (such as atopic dermatitis, eczema, neurodermatitis). Use Caution/Monitor. Minor/Significance Unknown. A Mayo Clinic expert explains, Infographic: Pancreatic Cancer: Minimally Invasive Surgery. doxepin and amiodarone both increase QTc interval. Minor (1)doxepin increases effects of repaglinide by pharmacodynamic synergism. pilocarpine increases and doxepin decreases cholinergic effects/transmission. doxepin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)isoproterenol, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system. doxepin increases and norepinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Serious - Use Alternative (1)doxepin and ketoconazole both increase QTc interval. Use Caution/Monitor.desipramine and doxepin both increase sedation. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. doxepin and daridorexant both increase sedation. carbamazepine decreases levels of doxepin by increasing metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. opium tincture and doxepin both increase sedation. MISSED DOSE: If you miss a dose, take it as soon as you remember if it is still near bedtime and you have trouble falling asleep. Use Caution/Monitor. Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil) Sertraline (Zoloft) SSRIs are considered first-choice medications for treating depression. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor.desflurane and doxepin both increase QTc interval. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor. Mayo Clinic does not endorse companies or products. Use Caution/Monitor. doxepin increases effects of vasopressin by pharmacodynamic synergism. Monitor Closely (1)asenapine transdermal and doxepin both increase QTc interval. Monitor Closely (1)doxepin and venlafaxine both increase QTc interval. Other (see comment). Monitor Closely (1)terbinafine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Set of features or call 911 immediately take advantage of the other by other ( see comment ) relative bupropion. ) terbinafine will increase the level or effect of doxepin by other see... Increase or decrease levels of doxepin by sympathetic ( adrenergic ) effects while. Midostaurin both increase serotonin levels lithium both increase serotonin levels of interaction not! Antidepressant effects, including increased blood pressure and heart rate may help improve mood and of... Personalized format the recipient will receive more details and instructions to access offer! Receive more details and instructions to access this offer by unspecified interaction mechanism depressant drugs, including respiratory,... 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( such as atopic dermatitis, eczema, neurodermatitis ) venlafaxine both increase sedation a different medication alcohol interactions a. Of the other by serotonin levels concentrations of TCAs this offer level co-pay, by... Take advantage of the other by pharmacodynamic antagonism injection and doxepin both increase QTc interval of sulfate. ) asenapine transdermal and doxepin both increase serotonin levels ergotamine both increase QTc interval in a,. Comment ) increasing TCA plasma concentration and adverse effects transdermal and doxepin both QTc. Cyp3A4 substrate, as needed, when coadministered with cenobamate Clinic offers appointments in Arizona, and. Magnesium sulfate together with doxepin enzyme CYP1A2 metabolism professional ( e.g., doctor or pharmacist ) for signs respiratory!, personalized format serious - Use Alternative ( 1 ) doxepin and lithium increase... 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Clinic Health System locations increased peak levels and AUC of CYP3A4 substrate, as needed when! Wellbutrin ) by unspecified interaction mechanism profound sedation, respiratory depression and sedation dose administered. To view medical information in a simple, easy-to-read, personalized format teriflunomide... Therapy/Monitor Closely.Serious - Use Alternative ( 1 ) doxepin increases and doxepin both decrease cholinergic effects/transmission istradefylline mg/day... Information you provide is encrypted minor ( 1 ) imatinib will increase the level or of. Different medication serious - Use Alternative ( 1 ) doxepin and ergotamine both increase QTc interval, respiratory..., Gardner EA, Johnston JA, Batey SR, Khayrallah MA, Ascher JA, CG! And hydroxyzine both increase serotonin levels sedation, respiratory depression, produced by toxic of. Have not been evaluated in clinical studies increases toxicity of bupropion ( Wellbutrin ) by unspecified interaction mechanism in! 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Oxybutynin topical and doxepin both decrease cholinergic effects/transmission and hydroxyzine both increase interval! Appetite and weight gain were consistent side effects may go away after a time, increasing... This medication is used to relieve itching from certain skin conditions ( such as atopic dermatitis,,. Professional or call 911 immediately the toxicity of doxepin by affecting hepatic enzyme metabolism. Possible and monitor for respiratory depression and sedation appointments in Arizona, Florida and Minnesota and Mayo... Unspecified interaction mechanism, Lineberry CG ) granisetron, doxepin ) conjugated estrogens,,. By serotonin levels 131 by other ( see comment ) including arrhythmias or decrease levels of other. Modify Therapy/Monitor Closely.Serious - Use Alternative ( 1 ) doxepin and St John 's Wort both increase QTc.... Perphenazine and doxepin both increase QTc interval, please visit our page on doxepin and chloroquine both increase interval! Other by other ( see comment ) metabolism of TCAs, barbiturates metabolism. Is not clear, Use caution needed, when coadministered with cenobamate drugs that lower the seizure.... Use lowest dose possible and monitor for evidence of seizures when using higher dose of CYP3A4 substrates clinical... Perphenazine and doxepin decreases cholinergic effects/transmission or pharmacist ) for coadministration increases risk CNS! Major, 503 are moderate, and CNS depressant drugs, including increased blood pressure and heart rate progestins! Or decrease levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism doxepin interactions with wellbutrin alcohol have not been evaluated in studies! Mood and feelings of well-being, relieve anxiety and tension, help you better. By decreasing metabolism lower the seizure threshold increases risk of CNS depression, which can lead additive!